Erratum: Corrigendum to "Synthesis and Characterization of New Palladium(II) Thiosemicarbazone Complexes and Their Cytotoxic Activity against Various Human Tumor Cell Lines" (Folia Microbiologica (2007) 52 (15-25) (DOI:10.1155/2015/915270)): Synthesis and Characterization of New Palladium(II) Thiosemicarbazone Complexes and Their Cytotoxic Activity against Various Human Tumor Cell Lines

Wilfredo Hernandez, Juan Paz, Fernando Carrasco, Abraham Vaisberg, Evgenia Spodine, Jorge Manzur, Lothar Hennig, Joachim Sieler, Steffen Blaurock, Lothar Beyer

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Abstract

The palladium(II) bis-chelate complexes of the type [Pd(TSC1−5)2] (6–10), with their corresponding ligands 4-phenyl-1-(acetone)-
thiosemicarbazone, HTSC1 (1), 4-phenyl-1-(2󸀠
-chloro-benzaldehyde)-thiosemicarbazone, HTSC2 (2), 4-phenyl-1-(3󸀠
-hydroxybenzaldehyde)-thiosemicarbazone, HTSC3 (3), 4-phenyl-1-(2󸀠
-naphthaldehyde)-thiosemicarbazone, HTSC4 (4), and 4-phenyl1-(1󸀠
-nitro-2󸀠
-naphthaldehyde)-thiosemicarbazone, HTSC5 (5), were synthesized and characterized by elemental analysis and
spectroscopic techniques (IR and 1
H- and 13C-NMR). The molecular structure of HTSC3
, HTSC4
, and [Pd(TSC1
)2] (6) have been
determined by single crystal X-ray crystallography. Complex 6 shows a square planar geometry with two deprotonated ligands
coordinated to PdII through the azomethine nitrogen and thione sulfur atoms in a cis arrangement. The in vitro cytotoxic activity
measurements indicate that the palladium(II) complexes (IC50 = 0.01–9.87 𝜇M) exhibited higher antiproliferative activity than
their free ligands (IC50 = 23.48–70.86 and >250 𝜇M) against different types of human tumor cell lines. Among all the studied
palladium(II) complexes, the [Pd(TSC3
)2] (8) complex exhibited high antitumor activity on the DU145 prostate carcinoma and
K562 chronic myelogenous leukemia cells, with low values of the inhibitory concentration (0.01 and 0.02 𝜇M, resp.).
Translated title of the contributionSynthesis and Characterization of New Palladium(II) Thiosemicarbazone Complexes and Their Cytotoxic Activity against Various Human Tumor Cell Lines: Synthesis and Characterization of New Palladium(II) Thiosemicarbazone Complexes and Their Cytotoxic Activity against Various Human Tumor Cell Lines
Original languageAmerican English
Pages (from-to)1-12
Number of pages12
JournalBioinorganic Chemistry and Applications
DOIs
StatePublished - 1 Jan 2015

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