STD NMR spectroscopy: A case study of fosfomycin binding interactions in living bacterial cells

Cíntia D.F. Milagre, Luís Fernando Cabeça, Lucas G. Martins, Anita J. Marsaioli

Research output: Contribution to journalArticle (Contribution to Journal)

5 Scopus citations

Abstract

A saturation transfer difference (STD) NMR experiment was successfully employed to observe the binding interactions of fosfomycin resistant and non-resistant bacterial strains using living cell suspensions, without the need for isotopic labelling of the ligand or receptor.

Original languageEnglish
Pages (from-to)286-291
Number of pages6
JournalJournal of the Brazilian Chemical Society
Volume22
Issue number2
DOIs
StatePublished - 2011
Externally publishedYes

Keywords

  • Fosfomycin
  • Ligand-target interactions
  • Liposomes
  • Membrane-bound proteins
  • STD NMR in living bacterial cells

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