1H NMR studies of binary and ternary dapsone supramolecular complexes with different drug carriers: EPC liposome, SBE-β-CD and β-CD

Lucas Martins, Monica Arrais, Alexandre De Souza, Anita Marsaioli

Research output: Contribution to journalArticle (Contribution to Journal)

6 Scopus citations

Abstract

Binary and ternary systems composed of dapsone, sulfobutylether-β-cyclodextrin (SBE-β-CD), β-CD and egg phosphatidylcholine (EPC) were evaluated using 1D ROESY, saturation transfer difference NMR and diffusion experiments (DOSY) revealing the binary complexes Dap/β-CD (Ka 1396 lmol-1), Dap/SBE-β-CD (Ka 246 lmol-1), Dap/EPC (Ka 84 lmol-1) and the ternary complex Dap/β-CD/EPC (Ka 18 lmol-1) in which dapsone is more soluble.

Original languageEnglish
Pages (from-to)665-672
Number of pages8
JournalMagnetic Resonance in Chemistry
Volume52
Issue number11
DOIs
StatePublished - Nov 2014
Externally publishedYes

Keywords

  • Dapsone
  • EPC liposome
  • NMR
  • SBE-β-CD
  • β-CD

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