1H NMR studies of binary and ternary dapsone supramolecular complexes with different drug carriers: EPC liposome, SBE-β-CD and β-CD

Lucas Martins; Monica Arrais; Alexandre De Souza; Anita Marsaioli

doi:10.1002/mrc.4087

¹H NMR studies of binary and ternary dapsone supramolecular complexes with different drug carriers: EPC liposome, SBE-β-CD and β-CD

Lucas Martins
, Monica Arrais
, Alexandre De Souza
, Anita Marsaioli

Research output: Contribution to journal › Article (Contribution to Journal) › peer-review

8 Scopus citations

Abstract

Binary and ternary systems composed of dapsone, sulfobutylether-β-cyclodextrin (SBE-β-CD), β-CD and egg phosphatidylcholine (EPC) were evaluated using 1D ROESY, saturation transfer difference NMR and diffusion experiments (DOSY) revealing the binary complexes Dap/β-CD (K_a 1396 lmol^-1), Dap/SBE-β-CD (K_a 246 lmol^-1), Dap/EPC (K_a 84 lmol^-1) and the ternary complex Dap/β-CD/EPC (K_a 18 lmol^-1) in which dapsone is more soluble.

Original language	English
Pages (from-to)	665-672
Number of pages	8
Journal	Magnetic Resonance in Chemistry
Volume	52
Issue number	11
DOIs	https://doi.org/10.1002/mrc.4087
State	Published - Nov 2014
Externally published	Yes

Keywords

Dapsone
EPC liposome
NMR
SBE-β-CD
β-CD

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10.1002/mrc.4087

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title = "1H NMR studies of binary and ternary dapsone supramolecular complexes with different drug carriers: EPC liposome, SBE-β-CD and β-CD",

abstract = "Binary and ternary systems composed of dapsone, sulfobutylether-β-cyclodextrin (SBE-β-CD), β-CD and egg phosphatidylcholine (EPC) were evaluated using 1D ROESY, saturation transfer difference NMR and diffusion experiments (DOSY) revealing the binary complexes Dap/β-CD (Ka 1396 lmol-1), Dap/SBE-β-CD (Ka 246 lmol-1), Dap/EPC (Ka 84 lmol-1) and the ternary complex Dap/β-CD/EPC (Ka 18 lmol-1) in which dapsone is more soluble.",

keywords = "Dapsone, EPC liposome, NMR, SBE-β-CD, β-CD",

author = "Lucas Martins and Monica Arrais and \{De Souza\}, Alexandre and Anita Marsaioli",

note = "Publisher Copyright: Copyright {\textcopyright} 2014 John Wiley \& Sons, Ltd.",

year = "2014",

month = nov,

doi = "10.1002/mrc.4087",

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volume = "52",

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TY - JOUR

T1 - 1H NMR studies of binary and ternary dapsone supramolecular complexes with different drug carriers

T2 - EPC liposome, SBE-β-CD and β-CD

AU - Martins, Lucas

AU - Arrais, Monica

AU - De Souza, Alexandre

AU - Marsaioli, Anita

PY - 2014/11

Y1 - 2014/11

N2 - Binary and ternary systems composed of dapsone, sulfobutylether-β-cyclodextrin (SBE-β-CD), β-CD and egg phosphatidylcholine (EPC) were evaluated using 1D ROESY, saturation transfer difference NMR and diffusion experiments (DOSY) revealing the binary complexes Dap/β-CD (Ka 1396 lmol-1), Dap/SBE-β-CD (Ka 246 lmol-1), Dap/EPC (Ka 84 lmol-1) and the ternary complex Dap/β-CD/EPC (Ka 18 lmol-1) in which dapsone is more soluble.

AB - Binary and ternary systems composed of dapsone, sulfobutylether-β-cyclodextrin (SBE-β-CD), β-CD and egg phosphatidylcholine (EPC) were evaluated using 1D ROESY, saturation transfer difference NMR and diffusion experiments (DOSY) revealing the binary complexes Dap/β-CD (Ka 1396 lmol-1), Dap/SBE-β-CD (Ka 246 lmol-1), Dap/EPC (Ka 84 lmol-1) and the ternary complex Dap/β-CD/EPC (Ka 18 lmol-1) in which dapsone is more soluble.

KW - Dapsone

KW - EPC liposome

KW - NMR

KW - SBE-β-CD

KW - β-CD

UR - https://www.scopus.com/pages/publications/84914816951

U2 - 10.1002/mrc.4087

DO - 10.1002/mrc.4087

M3 - Artículo (Contribución a Revista)

C2 - 25042274

AN - SCOPUS:84914816951

SN - 0749-1581

VL - 52

SP - 665

EP - 672

JO - Magnetic Resonance in Chemistry

JF - Magnetic Resonance in Chemistry

IS - 11

ER -

¹H NMR studies of binary and ternary dapsone supramolecular complexes with different drug carriers: EPC liposome, SBE-β-CD and β-CD

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Keywords

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