TY - JOUR
T1 - Synthesis and characterization of new palladium(II) complexes with ligands derived from furan-2-carbaldehyde and benzaldehyde thiosemicarbazone and their in vitro cytotoxic activities against various human tumor cell lines
AU - Hernández, Wilfredo
AU - Paz, Juan
AU - Carrasco, Fernando
AU - Vaisberg, Abraham
AU - Manzur, Jorge
AU - Spodine, Evgenia
AU - Hennig, Lothar
AU - Sieler, Joachim
AU - Beyer, Lothar
PY - 2010/1/1
Y1 - 2010/1/1
N2 - With the ligands 4-phenyl-1-(furan-2-carbaldehyde)thiosemicarbazone, HTSC', (1), 4-phenyl-1- (5'-phenyl-furan-2-carbaldehyde)thiosemicarbazone, HTSC 2 (2), o-methoxy-benzaldehydethiosemicarbazone, HTSC3 (3), and o-cyano-benzaldehydethiosemicarbazone, HTSC4 (4), the corresponding palladium(II) complexes, Pd(TSC1)2 (5), Pd(TSC2)2 (6), Pd(TSC3)2 (7), and Pd(TSC4)2 (8) were synthesized and characterized by elemental analysis and spectroscopic techniques. The crystal structure of Pd(TSC3)2 (7) was determined by single-crystal X-ray diffraction. Complex 7 shows a squareplanar geometry, where two deprotonated ligands are coordinated to the PdII center through the nitrogen and sulfur atoms in a trans arrangement. In vitro antitumor studies against different human tumor cell lines have revealed that the palladium(II) complexes 5- 8 are more cytotoxic (IC50 values in the range of 0.21 - 3.79 μM) than their corresponding ligands (1 - 4) (> 60 μM). These results indicate that the antiproliferative activity is enhanced when thiosemicarbazone ligands are coordinated to the metal. Among the studied palladium(II) complexes, 8 exhibits high antitumor activity on K562 chronic myelogenous leukemia cells with a low value of the inhibitory concentration (IC50 = 0.21 μM). © 2010 Verlag der Zeitschrift für Naturforschung, Tübingen.
AB - With the ligands 4-phenyl-1-(furan-2-carbaldehyde)thiosemicarbazone, HTSC', (1), 4-phenyl-1- (5'-phenyl-furan-2-carbaldehyde)thiosemicarbazone, HTSC 2 (2), o-methoxy-benzaldehydethiosemicarbazone, HTSC3 (3), and o-cyano-benzaldehydethiosemicarbazone, HTSC4 (4), the corresponding palladium(II) complexes, Pd(TSC1)2 (5), Pd(TSC2)2 (6), Pd(TSC3)2 (7), and Pd(TSC4)2 (8) were synthesized and characterized by elemental analysis and spectroscopic techniques. The crystal structure of Pd(TSC3)2 (7) was determined by single-crystal X-ray diffraction. Complex 7 shows a squareplanar geometry, where two deprotonated ligands are coordinated to the PdII center through the nitrogen and sulfur atoms in a trans arrangement. In vitro antitumor studies against different human tumor cell lines have revealed that the palladium(II) complexes 5- 8 are more cytotoxic (IC50 values in the range of 0.21 - 3.79 μM) than their corresponding ligands (1 - 4) (> 60 μM). These results indicate that the antiproliferative activity is enhanced when thiosemicarbazone ligands are coordinated to the metal. Among the studied palladium(II) complexes, 8 exhibits high antitumor activity on K562 chronic myelogenous leukemia cells with a low value of the inhibitory concentration (IC50 = 0.21 μM). © 2010 Verlag der Zeitschrift für Naturforschung, Tübingen.
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U2 - 10.1515/znb-2010-1015
DO - 10.1515/znb-2010-1015
M3 - Article (Contribution to Journal)
SP - 1271
EP - 1278
JO - Zeitschrift fur Naturforschung - Section B Journal of Chemical Sciences
JF - Zeitschrift fur Naturforschung - Section B Journal of Chemical Sciences
SN - 0932-0776
ER -