Synthesis and characterization of new palladium(II) complexes with ligands derived from furan-2-carbaldehyde and benzaldehyde thiosemicarbazone and their in vitro cytotoxic activities against various human tumor cell lines

Wilfredo Hernández, Juan Paz, Fernando Carrasco, Abraham Vaisberg, Jorge Manzur, Evgenia Spodine, Lothar Hennig, Joachim Sieler, Lothar Beyer

Research output: Contribution to journalArticle (Contribution to Journal)

5 Scopus citations

Abstract

With the ligands 4-phenyl-1-(furan-2-carbaldehyde)thiosemicarbazone, HTSC', (1), 4-phenyl-1- (5'-phenyl-furan-2-carbaldehyde)thiosemicarbazone, HTSC 2 (2), o-methoxy-benzaldehydethiosemicarbazone, HTSC3 (3), and o-cyano-benzaldehydethiosemicarbazone, HTSC4 (4), the corresponding palladium(II) complexes, Pd(TSC1)2 (5), Pd(TSC2)2 (6), Pd(TSC3)2 (7), and Pd(TSC4)2 (8) were synthesized and characterized by elemental analysis and spectroscopic techniques. The crystal structure of Pd(TSC3)2 (7) was determined by single-crystal X-ray diffraction. Complex 7 shows a squareplanar geometry, where two deprotonated ligands are coordinated to the PdII center through the nitrogen and sulfur atoms in a trans arrangement. In vitro antitumor studies against different human tumor cell lines have revealed that the palladium(II) complexes 5- 8 are more cytotoxic (IC50 values in the range of 0.21 - 3.79 μM) than their corresponding ligands (1 - 4) (> 60 μM). These results indicate that the antiproliferative activity is enhanced when thiosemicarbazone ligands are coordinated to the metal. Among the studied palladium(II) complexes, 8 exhibits high antitumor activity on K562 chronic myelogenous leukemia cells with a low value of the inhibitory concentration (IC50 = 0.21 μM). © 2010 Verlag der Zeitschrift für Naturforschung, Tübingen.
Original languageAmerican English
Pages (from-to)1271-1278
Number of pages8
JournalZeitschrift fur Naturforschung - Section B Journal of Chemical Sciences
DOIs
StatePublished - 1 Jan 2010

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