Synthesis and characterization of New Palladium(II) thiosemicarbazone complexes and their cytotoxic activity against various human tumor cell lines

Wilfredo Hernández, Juan Paz, Fernando Carrasco, Abraham Vaisberg, Evgenia Spodine, Jorge Manzur, Lothar Hennig, Joachim Sieler, Steffen Blaurock, Lothar Beyer

Research output: Contribution to journalArticle (Contribution to Journal)peer-review

14 Scopus citations

Abstract

The palladium(II) bis-chelate complexes of the type [Pd(TSC 1-5)2] (6-10), with their corresponding ligands 4-phenyl-1-(acetone)-thiosemicarbazone, HTSC1 (1), 4-phenyl-1-(2′-chloro-benzaldehyde)-thiosemicarbazone, HTSC2 (2), 4-phenyl-1-(3′-hydroxy-benzaldehyde)-thiosemicarbazone, HTSC 3 (3), 4-phenyl-1-(2′-naphthaldehyde)-thiosemicarbazone, HTSC4 (4), and 4-phenyl-1-(1′-nitro-2′-naphthaldehyde)- thiosemicarbazone, HTSC5 (5), were synthesized and characterized by elemental analysis and spectroscopic techniques (IR and 1H- and 13C-NMR). The molecular structure of HTSC3, HTSC 4, and [Pd(TSC1)2] (6) have been determined by single crystal X-ray crystallography. Complex 6 shows a square planar geometry with two deprotonated ligands coordinated to P d II through the azomethine nitrogen and thione sulfur atoms in a cis arrangement. The in vitro cytotoxic activity measurements indicate that the palladium(II) complexes (I C 50 = 0.01 -9.87 M) exhibited higher antiproliferative activity than their free ligands (I C 50 = 23.48 -70.86 and >250 M) against different types of human tumor cell lines. Among all the studied palladium(II) complexes, the [Pd(TSC 3)2] (8) complex exhibited high antitumor activity on the DU145 prostate carcinoma and K562 chronic myelogenous leukemia cells, with low values of the inhibitory concentration (0.01 and 0.02 M, resp.). © 2013 Wilfredo Hernández et al.
Original languageAmerican English
JournalBioinorganic Chemistry and Applications
DOIs
StatePublished - 1 Dec 2013

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