Synthesis, characterization and cytotoxicity of novel platinum(II) complexes with furan-2-carbaldehyde thiosemicarbazones

Fernando Carlos Carrasco Solis; Wilfredo Román Hernandez Gorritti; Evgenia Spodine; Maik Icker; Harald Krautscheid; Lothar Beyer

Synthesis, characterization and cytotoxicity of novel platinum(II) complexes with furan-2-carbaldehyde thiosemicarbazones

Fernando Carlos Carrasco Solis
, Wilfredo Román Hernandez Gorritti
, Evgenia Spodine
, Maik Icker
, Harald Krautscheid
, Lothar Beyer

Research output: Chapter in Book/Report/Conference proceeding › Paper (Conference contribution) › peer-review

Abstract

The platinum(II) bis-chelate complexes of the type [Pt(TSC1-7)2] (8-14) with their corresponding ligands derived from furan-2-carbaldehyde thiosemicarbazone were synthesized, and characterized by ESI-mass, FT-IR and NMR (1H, 13C) spectroscopy. The ligands deprotonated at the NH group are coordinated to PtII ions through the nitrogen and sulphur atoms. According to in vitro cytotoxic evaluation, the platinum(II) complexes (IC50 = <1.61-9.71 μM) exhibited higher antiproliferative activity, than their free ligands (IC50 = 13.36- >372.34 μM), against different types of human tumor cell lines. Among all the studied platinum(II) complexes, Pt(TSC4)2 (11) and Pt(TSC7)2 (14) exhibited high antitumor activity on the HuTu80 duodenum adenocarcinoma cells, with low values of the inhibitory concentration (<1.61 and 3.49 μM, respectively).

Original language	Spanish (Peru)
Title of host publication	Synthesis, characterization and cytotoxicity of novel platinum(II) complexes with furan-2-carbaldehyde thiosemicarbazones
State	Published - 29 Apr 2023

Cite this

@inproceedings{1b0f273c20ba4e4994332d212b84cced,

title = "Synthesis, characterization and cytotoxicity of novel platinum(II) complexes with furan-2-carbaldehyde thiosemicarbazones",

abstract = "The platinum(II) bis-chelate complexes of the type [Pt(TSC1-7)2] (8-14) with their corresponding ligands derived from furan-2-carbaldehyde thiosemicarbazone were synthesized, and characterized by ESI-mass, FT-IR and NMR (1H, 13C) spectroscopy. The ligands deprotonated at the NH group are coordinated to PtII ions through the nitrogen and sulphur atoms. According to in vitro cytotoxic evaluation, the platinum(II) complexes (IC50 = <1.61-9.71 μM) exhibited higher antiproliferative activity, than their free ligands (IC50 = 13.36- >372.34 μM), against different types of human tumor cell lines. Among all the studied platinum(II) complexes, Pt(TSC4)2 (11) and Pt(TSC7)2 (14) exhibited high antitumor activity on the HuTu80 duodenum adenocarcinoma cells, with low values of the inhibitory concentration (<1.61 and 3.49 μM, respectively). ",

author = "\{Carrasco Solis\}, \{Fernando Carlos\} and \{Hernandez Gorritti\}, \{Wilfredo Rom{\'a}n\} and Evgenia Spodine and Maik Icker and Harald Krautscheid and Lothar Beyer",

year = "2023",

month = apr,

day = "29",

language = "Espa{\~n}ol (Per{\'u})",

booktitle = "Synthesis, characterization and cytotoxicity of novel platinum(II) complexes with furan-2-carbaldehyde thiosemicarbazones",

}

Synthesis, characterization and cytotoxicity of novel platinum(II) complexes with furan-2-carbaldehyde thiosemicarbazones. / Carrasco Solis, Fernando Carlos ; Hernandez Gorritti, Wilfredo Román; Spodine, Evgenia et al.
Synthesis, characterization and cytotoxicity of novel platinum(II) complexes with furan-2-carbaldehyde thiosemicarbazones. 2023.

Research output: Chapter in Book/Report/Conference proceeding › Paper (Conference contribution) › peer-review

TY - GEN

T1 - Synthesis, characterization and cytotoxicity of novel platinum(II) complexes with furan-2-carbaldehyde thiosemicarbazones

AU - Carrasco Solis, Fernando Carlos

AU - Hernandez Gorritti, Wilfredo Román

AU - Spodine, Evgenia

AU - Icker, Maik

AU - Krautscheid, Harald

AU - Beyer, Lothar

PY - 2023/4/29

Y1 - 2023/4/29

N2 - The platinum(II) bis-chelate complexes of the type [Pt(TSC1-7)2] (8-14) with their corresponding ligands derived from furan-2-carbaldehyde thiosemicarbazone were synthesized, and characterized by ESI-mass, FT-IR and NMR (1H, 13C) spectroscopy. The ligands deprotonated at the NH group are coordinated to PtII ions through the nitrogen and sulphur atoms. According to in vitro cytotoxic evaluation, the platinum(II) complexes (IC50 = <1.61-9.71 μM) exhibited higher antiproliferative activity, than their free ligands (IC50 = 13.36- >372.34 μM), against different types of human tumor cell lines. Among all the studied platinum(II) complexes, Pt(TSC4)2 (11) and Pt(TSC7)2 (14) exhibited high antitumor activity on the HuTu80 duodenum adenocarcinoma cells, with low values of the inhibitory concentration (<1.61 and 3.49 μM, respectively).

AB - The platinum(II) bis-chelate complexes of the type [Pt(TSC1-7)2] (8-14) with their corresponding ligands derived from furan-2-carbaldehyde thiosemicarbazone were synthesized, and characterized by ESI-mass, FT-IR and NMR (1H, 13C) spectroscopy. The ligands deprotonated at the NH group are coordinated to PtII ions through the nitrogen and sulphur atoms. According to in vitro cytotoxic evaluation, the platinum(II) complexes (IC50 = <1.61-9.71 μM) exhibited higher antiproliferative activity, than their free ligands (IC50 = 13.36- >372.34 μM), against different types of human tumor cell lines. Among all the studied platinum(II) complexes, Pt(TSC4)2 (11) and Pt(TSC7)2 (14) exhibited high antitumor activity on the HuTu80 duodenum adenocarcinoma cells, with low values of the inhibitory concentration (<1.61 and 3.49 μM, respectively).

M3 - Articulo (Contribución a conferencia)

BT - Synthesis, characterization and cytotoxicity of novel platinum(II) complexes with furan-2-carbaldehyde thiosemicarbazones

ER -