Proyectos por año
Resumen
Four indole-3-carbaldehyde semicarbazone derivatives, 2-((5-bromo-1H-indol-3-yl)methylene)hydrazinecarboxamide (1), 2-((5-
chloro-1H-indol-3-yl)methylene)hydrazinecarboxamide (2), 2-((5-methoxy-1H-indol-3-yl)methylene)hydrazinecarboxamide (3), and
2-((4-nitro-1H-indol-3-yl)methylene)hydrazinecarboxamide (4) were synthesized and characterized by ESI-MS and spectroscopic (FTIR, 1
H NMR, and 13C NMR) techniques.6e two-dimensional NMR (in acetone-d6) spectral data revealed that the molecules 1 and 2 in
solution are in the cisE isomeric form.6is evidence is supported by DFTcalculations at the B3LYP/6-311++G(d,p) level of theory where
it was shown that the corresponding most stable conformers of the synthesized compounds have a cisE geometrical configuration, in both the gas and liquid (acetone and DMSO) phases.6e in vitro antibacterial activity of compounds 1–4was determined against Grampositive (Staphylococcus aureus and Bacillus subtilis) and Gram-negative (Pseudomonas aeruginosa and Escherichia coli) bacteria. Among all the tested semicarbazones, 1 and 2 exhibited similar inhibitory activities against Staphylococcus aureus (MIC� 100 and
150 μg/mL, respectively) and Bacillus subtilis (MIC� 100 and 150 μg/mL, respectively). On the other hand, 3 and 4 were relatively less
active against the tested bacterial strains compared with 1, 2, and tetracycline.
chloro-1H-indol-3-yl)methylene)hydrazinecarboxamide (2), 2-((5-methoxy-1H-indol-3-yl)methylene)hydrazinecarboxamide (3), and
2-((4-nitro-1H-indol-3-yl)methylene)hydrazinecarboxamide (4) were synthesized and characterized by ESI-MS and spectroscopic (FTIR, 1
H NMR, and 13C NMR) techniques.6e two-dimensional NMR (in acetone-d6) spectral data revealed that the molecules 1 and 2 in
solution are in the cisE isomeric form.6is evidence is supported by DFTcalculations at the B3LYP/6-311++G(d,p) level of theory where
it was shown that the corresponding most stable conformers of the synthesized compounds have a cisE geometrical configuration, in both the gas and liquid (acetone and DMSO) phases.6e in vitro antibacterial activity of compounds 1–4was determined against Grampositive (Staphylococcus aureus and Bacillus subtilis) and Gram-negative (Pseudomonas aeruginosa and Escherichia coli) bacteria. Among all the tested semicarbazones, 1 and 2 exhibited similar inhibitory activities against Staphylococcus aureus (MIC� 100 and
150 μg/mL, respectively) and Bacillus subtilis (MIC� 100 and 150 μg/mL, respectively). On the other hand, 3 and 4 were relatively less
active against the tested bacterial strains compared with 1, 2, and tetracycline.
Título traducido de la contribución | Derivados del Indol-3-carbaldehído semicarbazona: síntesis, caracterización y actividades antibacterianas: Derivados del Indol-3-carbaldehído semicarbazona: síntesis, caracterización y actividades antibacterianas |
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Idioma original | Inglés |
Número de artículo | 7157281 |
Páginas (desde-hasta) | 1-9 |
Número de páginas | 9 |
Publicación | Journal of Chemistry |
Volumen | 2020 |
DOI | |
Estado | Publicada - 1 ene. 2020 |
COAR
- Artículo
Categoría OCDE
- Ciencias naturales
Categorías Repositorio Ulima
- Ciencias / Medicina y Salud
Temas Repositorio Ulima
- Chemistry, Organic
- Compuestos orgánicos
- Organic compounds
- Química orgánica
Proyectos
- 1 Terminado
-
QMI: Nuevos complejos de platino(II) y paladio(II) con derivados del furano-2-carbaldehído tiosemicarbazona y su actividad antitumoral
Hernández Gorritti, W. R. (Investigador principal), Carrasco Solis, F. C. (Investigador adjunto), Vaisberg, A. J. (Investigador adjunto), Spodine, E. (Investigador adjunto), Icker, M. (Investigador adjunto), Krautscheid, H. (Investigador adjunto) & Beyer, L. (Investigador adjunto)
1/04/21 → 31/03/22
Proyecto: Investigación