Indole-3-carbaldehyde Semicarbazone Derivatives: Synthesis, Characterization, and Antibacterial Activities

Wilfredo Hernández, Fernando Carrasco, Oscar Chupayo, Celedonio M. Álvarez, Sandra Oramas-Royo, Evgenia Spodine, Carmen Tamariz-Angeles, Percy Olivera-Gonzales, Juan Z. Dávalos

Resultado de la investigación: Contribución a una revistaArtículo (Contribución a Revista)revisión exhaustiva

2 Citas (Scopus)

Resumen

The two-dimensional NMR (in acetone-d6) spectral data revealed that the molecules 1 and 2 in solution are in the cisE isomeric form. This evidence is supported by DFT calculations at the B3LYP/6-311++G(d,p) level of theory where it was shown that the corresponding most stable conformers of the synthesized compounds have a cisE geometrical configuration, in both the gas and liquid (acetone and DMSO) phases. The in vitro antibacterial activity of compounds 1-4 was determined against Gram-positive (Staphylococcus aureus and Bacillus subtilis) and Gram-negative (Pseudomonas aeruginosa and Escherichia coli) bacteria. Among all the tested semicarbazones, 1 and 2 exhibited similar inhibitory activities against Staphylococcus aureus (MIC = 100 and 150 µg/mL, respectively) and Bacillus subtilis (MIC = 100 and 150 µg/mL, respectively). On the other hand, 3 and 4 were relatively less active against the tested bacterial strains compared with 1, 2, and tetracycline. © 2020 Fernando Carrasco et al.
Idioma originalInglés
Número de artículo7157281
PublicaciónJournal of Chemistry
Volumen2020
DOI
EstadoPublicada - 1 ene 2020

COAR

  • Artículo

Categoría OCDE

  • Ciencias naturales

Categorías Repositorio Ulima

  • Ciencias / Medicina y Salud

Temas Repositorio Ulima

  • Chemistry, Organic
  • Compuestos orgánicos
  • Organic compounds
  • Química orgánica

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