1H NMR studies of binary and ternary dapsone supramolecular complexes with different drug carriers: EPC liposome, SBE-β-CD and β-CD

Lucas Martins; Monica Arrais; Alexandre De Souza; Anita Marsaioli

doi:10.1002/mrc.4087

¹H NMR studies of binary and ternary dapsone supramolecular complexes with different drug carriers: EPC liposome, SBE-β-CD and β-CD

Lucas Martins, Monica Arrais, Alexandre De Souza, Anita Marsaioli

Producción científica: Contribución a una revista › Artículo (Contribución a Revista) › revisión exhaustiva

8 Citas (Scopus)

Resumen

Binary and ternary systems composed of dapsone, sulfobutylether-β-cyclodextrin (SBE-β-CD), β-CD and egg phosphatidylcholine (EPC) were evaluated using 1D ROESY, saturation transfer difference NMR and diffusion experiments (DOSY) revealing the binary complexes Dap/β-CD (K_a 1396 lmol^-1), Dap/SBE-β-CD (K_a 246 lmol^-1), Dap/EPC (K_a 84 lmol^-1) and the ternary complex Dap/β-CD/EPC (K_a 18 lmol^-1) in which dapsone is more soluble.

Idioma original	Inglés
Páginas (desde-hasta)	665-672
Número de páginas	8
Publicación	Magnetic Resonance in Chemistry
Volumen	52
N.º	11
DOI	https://doi.org/10.1002/mrc.4087
Estado	Publicada - nov. 2014
Publicado de forma externa	Sí

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10.1002/mrc.4087

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@article{dafec6557c794cce8af2c919cefddb13,

title = "1H NMR studies of binary and ternary dapsone supramolecular complexes with different drug carriers: EPC liposome, SBE-β-CD and β-CD",

abstract = "Binary and ternary systems composed of dapsone, sulfobutylether-β-cyclodextrin (SBE-β-CD), β-CD and egg phosphatidylcholine (EPC) were evaluated using 1D ROESY, saturation transfer difference NMR and diffusion experiments (DOSY) revealing the binary complexes Dap/β-CD (Ka 1396 lmol-1), Dap/SBE-β-CD (Ka 246 lmol-1), Dap/EPC (Ka 84 lmol-1) and the ternary complex Dap/β-CD/EPC (Ka 18 lmol-1) in which dapsone is more soluble.",

keywords = "Dapsone, EPC liposome, NMR, SBE-β-CD, β-CD",

author = "Lucas Martins and Monica Arrais and {De Souza}, Alexandre and Anita Marsaioli",

note = "Publisher Copyright: Copyright {\textcopyright} 2014 John Wiley & Sons, Ltd.",

year = "2014",

month = nov,

doi = "10.1002/mrc.4087",

language = "Ingl{\'e}s",

volume = "52",

pages = "665--672",

journal = "Magnetic Resonance in Chemistry",

issn = "0749-1581",

number = "11",

}

¹H NMR studies of binary and ternary dapsone supramolecular complexes with different drug carriers: EPC liposome, SBE-β-CD and β-CD. / Martins, Lucas; Arrais, Monica; De Souza, Alexandre et al.
En: Magnetic Resonance in Chemistry, Vol. 52, N.º 11, 11.2014, p. 665-672.

Producción científica: Contribución a una revista › Artículo (Contribución a Revista) › revisión exhaustiva

TY - JOUR

T1 - 1H NMR studies of binary and ternary dapsone supramolecular complexes with different drug carriers

T2 - EPC liposome, SBE-β-CD and β-CD

AU - Martins, Lucas

AU - Arrais, Monica

AU - De Souza, Alexandre

AU - Marsaioli, Anita

PY - 2014/11

Y1 - 2014/11

N2 - Binary and ternary systems composed of dapsone, sulfobutylether-β-cyclodextrin (SBE-β-CD), β-CD and egg phosphatidylcholine (EPC) were evaluated using 1D ROESY, saturation transfer difference NMR and diffusion experiments (DOSY) revealing the binary complexes Dap/β-CD (Ka 1396 lmol-1), Dap/SBE-β-CD (Ka 246 lmol-1), Dap/EPC (Ka 84 lmol-1) and the ternary complex Dap/β-CD/EPC (Ka 18 lmol-1) in which dapsone is more soluble.

AB - Binary and ternary systems composed of dapsone, sulfobutylether-β-cyclodextrin (SBE-β-CD), β-CD and egg phosphatidylcholine (EPC) were evaluated using 1D ROESY, saturation transfer difference NMR and diffusion experiments (DOSY) revealing the binary complexes Dap/β-CD (Ka 1396 lmol-1), Dap/SBE-β-CD (Ka 246 lmol-1), Dap/EPC (Ka 84 lmol-1) and the ternary complex Dap/β-CD/EPC (Ka 18 lmol-1) in which dapsone is more soluble.

KW - Dapsone

KW - EPC liposome

KW - NMR

KW - SBE-β-CD

KW - β-CD

UR - http://www.scopus.com/inward/record.url?scp=84914816951&partnerID=8YFLogxK

U2 - 10.1002/mrc.4087

DO - 10.1002/mrc.4087

M3 - Artículo (Contribución a Revista)

C2 - 25042274

AN - SCOPUS:84914816951

SN - 0749-1581

VL - 52

SP - 665

EP - 672

JO - Magnetic Resonance in Chemistry

JF - Magnetic Resonance in Chemistry

IS - 11