Synthesis and characterization of new palladium(II) complexes with ligands derived from furan-2-carbaldehyde and benzaldehyde thiosemicarbazone and their in vitro cytotoxic activities against various human tumor cell lines

Wilfredo Hernández, Juan Paz, Fernando Carrasco, Abraham Vaisberg, Jorge Manzur, Evgenia Spodine, Lothar Hennig, Joachim Sieler, Lothar Beyer

Resultado de la investigación: Contribución a una revistaArtículo (Contribución a Revista)revisión exhaustiva

8 Citas (Scopus)

Resumen

With the ligands 4-phenyl-1-(furan-2-carbaldehyde)thiosemicarbazone, HTSC', (1), 4-phenyl-1- (5'-phenyl-furan-2-carbaldehyde)thiosemicarbazone, HTSC 2 (2), o-methoxy-benzaldehydethiosemicarbazone, HTSC3 (3), and o-cyano-benzaldehydethiosemicarbazone, HTSC4 (4), the corresponding palladium(II) complexes, Pd(TSC1)2 (5), Pd(TSC2)2 (6), Pd(TSC3)2 (7), and Pd(TSC4)2 (8) were synthesized and characterized by elemental analysis and spectroscopic techniques. The crystal structure of Pd(TSC3)2 (7) was determined by single-crystal X-ray diffraction. Complex 7 shows a squareplanar geometry, where two deprotonated ligands are coordinated to the PdII center through the nitrogen and sulfur atoms in a trans arrangement. In vitro antitumor studies against different human tumor cell lines have revealed that the palladium(II) complexes 5- 8 are more cytotoxic (IC50 values in the range of 0.21 - 3.79 μM) than their corresponding ligands (1 - 4) (> 60 μM). These results indicate that the antiproliferative activity is enhanced when thiosemicarbazone ligands are coordinated to the metal. Among the studied palladium(II) complexes, 8 exhibits high antitumor activity on K562 chronic myelogenous leukemia cells with a low value of the inhibitory concentration (IC50 = 0.21 μM). © 2010 Verlag der Zeitschrift für Naturforschung, Tübingen.
Idioma originalInglés estadounidense
Páginas (desde-hasta)1271-1278
Número de páginas8
PublicaciónZeitschrift fur Naturforschung - Section B Journal of Chemical Sciences
DOI
EstadoPublicada - 1 ene 2010

COAR

  • Artículo

Temas Repositorio Ulima

  • Cell line, Tumor
  • Línea celular tumoral
  • Paladio
  • Palladium
  • Thiosemicarbazones
  • Tiosemicarbazonas

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