Synthesis and Characterization of New Palladium(II) Thiosemicarbazone Complexes and Their Cytotoxic Activity against Various Human Tumor Cell Lines

Wilfredo Román Hernandez Gorritti; Juan Paz Castillo Berríos; Fernando Carlos Carrasco Solis; Abraham J. Vaisberg; Evgenia Spodine; Jorge Manzur; Lothar Hennig; Steffen Blaurock; Lothar Beyer

doi:10.1155/2013/524701

Synthesis and Characterization of New Palladium(II) Thiosemicarbazone Complexes and Their Cytotoxic Activity against Various Human Tumor Cell Lines

Título traducido de la contribución: Síntesis y caracterización de nuevos complejos de platino(II) con tiosemicarbazonas y sus actividades citotóxicas frente a varias líneas celulares tumorales de humano

Wilfredo Román Hernandez Gorritti, Juan Paz Castillo Berríos, Fernando Carlos Carrasco Solis, Abraham J. Vaisberg, Evgenia Spodine, Jorge Manzur, Lothar Hennig, Steffen Blaurock, Lothar Beyer

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25 Citas (Scopus)

Resumen

The palladium(II) bis-chelate complexes of the type [Pd(TSC1−5)2] (6–10), with their corresponding ligands 4-phenyl-1-(acetone)-
thiosemicarbazone, HTSC1 (1), 4-phenyl-1-(2󸀠-chloro-benzaldehyde)-thiosemicarbazone, HTSC2 (2), 4-phenyl-1-(3󸀠-hydroxybenzaldehyde)-
thiosemicarbazone, HTSC3 (3), 4-phenyl-1-(2󸀠-naphthaldehyde)-thiosemicarbazone, HTSC4 (4), and 4-phenyl-
1-(1󸀠-nitro-2󸀠-naphthaldehyde)-thiosemicarbazone, HTSC5 (5), were synthesized and characterized by elemental analysis and
spectroscopic techniques (IR and 1H- and 13C-NMR). The molecular structure of HTSC3, HTSC4, and [Pd(TSC1)2] (6) have been
determined by single crystal X-ray crystallography. Complex 6 shows a square planar geometry with two deprotonated ligands
coordinated to PdII through the azomethine nitrogen and thione sulfur atoms in a cis arrangement. The in vitro cytotoxic activity
measurements indicate that the palladium(II) complexes (IC50 = 0.01–9.87 𝜇M) exhibited higher antiproliferative activity than
their free ligands (IC50 = 23.48–70.86 and >250 𝜇M) against different types of human tumor cell lines. Among all the studied
palladium(II) complexes, the [Pd(TSC3)2] (8) complex exhibited high antitumor activity on the DU145 prostate carcinoma and
K562 chronic myelogenous leukemia cells, with low values of the inhibitory concentration (0.01 and 0.02 𝜇M, resp.).

Título traducido de la contribución	Síntesis y caracterización de nuevos complejos de platino(II) con tiosemicarbazonas y sus actividades citotóxicas frente a varias líneas celulares tumorales de humano
Idioma original	Inglés estadounidense
Número de artículo	ID 524701
Número de páginas	12
Publicación	Bioinorganic Chemistry and Applications
Volumen	2013
N.º	ID 524701
DOI	https://doi.org/10.1155/2013/524701 https://doi.org/10.1155/2013/524701
Estado	Publicada - 3 oct. 2013

COAR

Artículo

Categorías Repositorio Ulima

Ciencias / Química

Temas Repositorio Ulima

Cell line, Tumor
In vitro techniques
Línea celular tumoral
Paladio
Palladium
Thiosemicarbazones
Tiosemicarbazonas
Técnicas in vitro

ODS de las Naciones Unidas

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QMI: Nuevos complejos de platino(II) y paladio(II) con derivados del furano-2-carbaldehído tiosemicarbazona y su actividad antitumoral
Hernandez Gorritti, W. R. (Investigador principal), Carrasco Solis, F. C. (Investigador adjunto), Vaisberg, A. J. (Investigador adjunto), Spodine, E. (Investigador adjunto), Icker, M. (Investigador adjunto), Krautscheid, H. (Investigador adjunto) & Beyer, L. (Investigador adjunto)
1/04/21 → 31/03/22
Proyecto: Investigación

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Hernandez Gorritti, W. R., Paz Castillo Berríos, J., Carrasco Solis, F. C., Vaisberg, A. J., Spodine, E., Manzur, J., Hennig, L., Blaurock, S., & Beyer, L. (2013). Synthesis and Characterization of New Palladium(II) Thiosemicarbazone Complexes and Their Cytotoxic Activity against Various Human Tumor Cell Lines. Bioinorganic Chemistry and Applications, 2013(ID 524701), Artículo ID 524701. https://doi.org/10.1155/2013/524701, https://doi.org/10.1155/2013/524701

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title = "Synthesis and Characterization of New Palladium(II) Thiosemicarbazone Complexes and Their Cytotoxic Activity against Various Human Tumor Cell Lines",

abstract = "The palladium(II) bis-chelate complexes of the type [Pd(TSC1−5)2] (6–10), with their corresponding ligands 4-phenyl-1-(acetone)-thiosemicarbazone, HTSC1 (1), 4-phenyl-1-(2耠-chloro-benzaldehyde)-thiosemicarbazone, HTSC2 (2), 4-phenyl-1-(3耠-hydroxybenzaldehyde)-thiosemicarbazone, HTSC3 (3), 4-phenyl-1-(2耠-naphthaldehyde)-thiosemicarbazone, HTSC4 (4), and 4-phenyl-1-(1耠-nitro-2耠-naphthaldehyde)-thiosemicarbazone, HTSC5 (5), were synthesized and characterized by elemental analysis andspectroscopic techniques (IR and 1H- and 13C-NMR). The molecular structure of HTSC3, HTSC4, and [Pd(TSC1)2] (6) have beendetermined by single crystal X-ray crystallography. Complex 6 shows a square planar geometry with two deprotonated ligandscoordinated to PdII through the azomethine nitrogen and thione sulfur atoms in a cis arrangement. The in vitro cytotoxic activitymeasurements indicate that the palladium(II) complexes (IC50 = 0.01–9.87 휇M) exhibited higher antiproliferative activity thantheir free ligands (IC50 = 23.48–70.86 and >250 휇M) against different types of human tumor cell lines. Among all the studiedpalladium(II) complexes, the [Pd(TSC3)2] (8) complex exhibited high antitumor activity on the DU145 prostate carcinoma andK562 chronic myelogenous leukemia cells, with low values of the inhibitory concentration (0.01 and 0.02 휇M, resp.).",

author = "{Hernandez Gorritti}, {Wilfredo Rom{\'a}n} and {Paz Castillo Berr{\'i}os}, Juan and {Carrasco Solis}, {Fernando Carlos} and Vaisberg, {Abraham J.} and Evgenia Spodine and Jorge Manzur and Lothar Hennig and Steffen Blaurock and Lothar Beyer",

year = "2013",

month = oct,

day = "3",

doi = "10.1155/2013/524701",

language = "American English",

volume = "2013",

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Hernandez Gorritti, WR, Paz Castillo Berríos, J, Carrasco Solis, FC, Vaisberg, AJ, Spodine, E, Manzur, J, Hennig, L, Blaurock, S & Beyer, L 2013, 'Synthesis and Characterization of New Palladium(II) Thiosemicarbazone Complexes and Their Cytotoxic Activity against Various Human Tumor Cell Lines', Bioinorganic Chemistry and Applications, vol. 2013, n.º ID 524701, ID 524701. https://doi.org/10.1155/2013/524701, https://doi.org/10.1155/2013/524701

Synthesis and Characterization of New Palladium(II) Thiosemicarbazone Complexes and Their Cytotoxic Activity against Various Human Tumor Cell Lines. / Hernandez Gorritti, Wilfredo Román; Paz Castillo Berríos, Juan; Carrasco Solis, Fernando Carlos et al.
En: Bioinorganic Chemistry and Applications, Vol. 2013, N.º ID 524701, ID 524701, 03.10.2013.

Producción científica: Contribución a una revista › Artículo (Contribución a Revista) › revisión exhaustiva

TY - JOUR

T1 - Synthesis and Characterization of New Palladium(II) Thiosemicarbazone Complexes and Their Cytotoxic Activity against Various Human Tumor Cell Lines

AU - Hernandez Gorritti, Wilfredo Román

AU - Paz Castillo Berríos, Juan

AU - Carrasco Solis, Fernando Carlos

AU - Vaisberg, Abraham J.

AU - Spodine, Evgenia

AU - Manzur, Jorge

AU - Hennig, Lothar

AU - Blaurock, Steffen

AU - Beyer, Lothar

PY - 2013/10/3

Y1 - 2013/10/3

N2 - The palladium(II) bis-chelate complexes of the type [Pd(TSC1−5)2] (6–10), with their corresponding ligands 4-phenyl-1-(acetone)-thiosemicarbazone, HTSC1 (1), 4-phenyl-1-(2耠-chloro-benzaldehyde)-thiosemicarbazone, HTSC2 (2), 4-phenyl-1-(3耠-hydroxybenzaldehyde)-thiosemicarbazone, HTSC3 (3), 4-phenyl-1-(2耠-naphthaldehyde)-thiosemicarbazone, HTSC4 (4), and 4-phenyl-1-(1耠-nitro-2耠-naphthaldehyde)-thiosemicarbazone, HTSC5 (5), were synthesized and characterized by elemental analysis andspectroscopic techniques (IR and 1H- and 13C-NMR). The molecular structure of HTSC3, HTSC4, and [Pd(TSC1)2] (6) have beendetermined by single crystal X-ray crystallography. Complex 6 shows a square planar geometry with two deprotonated ligandscoordinated to PdII through the azomethine nitrogen and thione sulfur atoms in a cis arrangement. The in vitro cytotoxic activitymeasurements indicate that the palladium(II) complexes (IC50 = 0.01–9.87 휇M) exhibited higher antiproliferative activity thantheir free ligands (IC50 = 23.48–70.86 and >250 휇M) against different types of human tumor cell lines. Among all the studiedpalladium(II) complexes, the [Pd(TSC3)2] (8) complex exhibited high antitumor activity on the DU145 prostate carcinoma andK562 chronic myelogenous leukemia cells, with low values of the inhibitory concentration (0.01 and 0.02 휇M, resp.).

AB - The palladium(II) bis-chelate complexes of the type [Pd(TSC1−5)2] (6–10), with their corresponding ligands 4-phenyl-1-(acetone)-thiosemicarbazone, HTSC1 (1), 4-phenyl-1-(2耠-chloro-benzaldehyde)-thiosemicarbazone, HTSC2 (2), 4-phenyl-1-(3耠-hydroxybenzaldehyde)-thiosemicarbazone, HTSC3 (3), 4-phenyl-1-(2耠-naphthaldehyde)-thiosemicarbazone, HTSC4 (4), and 4-phenyl-1-(1耠-nitro-2耠-naphthaldehyde)-thiosemicarbazone, HTSC5 (5), were synthesized and characterized by elemental analysis andspectroscopic techniques (IR and 1H- and 13C-NMR). The molecular structure of HTSC3, HTSC4, and [Pd(TSC1)2] (6) have beendetermined by single crystal X-ray crystallography. Complex 6 shows a square planar geometry with two deprotonated ligandscoordinated to PdII through the azomethine nitrogen and thione sulfur atoms in a cis arrangement. The in vitro cytotoxic activitymeasurements indicate that the palladium(II) complexes (IC50 = 0.01–9.87 휇M) exhibited higher antiproliferative activity thantheir free ligands (IC50 = 23.48–70.86 and >250 휇M) against different types of human tumor cell lines. Among all the studiedpalladium(II) complexes, the [Pd(TSC3)2] (8) complex exhibited high antitumor activity on the DU145 prostate carcinoma andK562 chronic myelogenous leukemia cells, with low values of the inhibitory concentration (0.01 and 0.02 휇M, resp.).

UR - https://hdl.handle.net/20.500.12724/1489

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UR - https://www.scopus.com/inward/citedby.uri?partnerID=HzOxMe3b&scp=84893670113&origin=inward

U2 - 10.1155/2013/524701

DO - 10.1155/2013/524701

M3 - Article (Contribution to Journal)

SN - 1565-3633

VL - 2013

JO - Bioinorganic Chemistry and Applications

JF - Bioinorganic Chemistry and Applications

IS - ID 524701

M1 - ID 524701

ER -

Hernandez Gorritti WR, Paz Castillo Berríos J, Carrasco Solis FC, Vaisberg AJ, Spodine E, Manzur J et al. Synthesis and Characterization of New Palladium(II) Thiosemicarbazone Complexes and Their Cytotoxic Activity against Various Human Tumor Cell Lines. Bioinorganic Chemistry and Applications. 2013 Oct. 3;2013(ID 524701):ID 524701. doi: 10.1155/2013/524701, 10.1155/2013/524701

Synthesis and Characterization of New Palladium(II) Thiosemicarbazone Complexes and Their Cytotoxic Activity against Various Human Tumor Cell Lines

Resumen

COAR

Categorías Repositorio Ulima

Temas Repositorio Ulima

ODS de las Naciones Unidas

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Otros archivos y enlaces

Proyectos

QMI: Nuevos complejos de platino(II) y paladio(II) con derivados del furano-2-carbaldehído tiosemicarbazona y su actividad antitumoral

Citar esto